◈ Topic : Networking metabolites, diseases, and drugs
◈ Speaker : Deok-Sun Lee, Ph.D. (Department of Natural Medical Sciences and Department of Physics Inha University)
◈ Date/Time : 3:00/Jan. 29(Fri)/2010
◈ Place : Life Science Building 104
◈ Information : Pro. Sang Uk Kim(T.279-2348)
◈ Abstract
We show simple analyses of human and bacterial metabolic networks can guide drug discovery and disease diagnosis/prevention. Chemical reaction fluxes in cellular metabolism are strongly correlated while consuming and producing metabolites either simultaneously or sequentially. We first discuss evidence that diseases'' comorbidity may be caused by such functional correlation of metabolic reactions. Next, we introduce an integrated drug discovery scheme for pathogenic bacteria, where a metabolic network analysis offers drug targets on the genome scale and computational chemistry provides drug candidates - small-molecule inhibitors of the targets.
