About the POSTECH Biotech Center
 

The Postech Biotech Center (PBC) was established in November 2000 in collaboration with POSCO, a world leader in steel industry and the founder of POSTECH, with the mission to grow into a world class biotech center that carries out cutting edge research and trains future leaders in biotechnology. The rationales behind this grandeur project of the nation ' s finest life-science research complex between academia and industry are to leverage the academic excellence achieved by POSTECH over the last decade, and to diversify the business portfolio of POSCO in an increasingly stagnant environment into the promising business of biotechnology.

The Center ' s four-story building (14,000 m 2 ), whose construction work started from December 2002 and was completed in July 2003, is characterized of the concept of Open Laboratories (no walls in between laboratories) to facilitate easy communication and exchange of ideas for collaborations beyond the boundaries of research. It also provides a wide range of state-of-the-art core technology facilities and a large number of specialty facilities including clean rooms for nanobiotech, green house, and germ-free animal rooms.

Following the lead of Professor Chi-Bom Chae, Head of the Division of Molecular and Life Sciences, the Center is empowered with a total of 35 professors with outstanding scientific achievements in biology, physics, chemistry, chemical engineering, and mechanical engineering. They are supported by a group of 90 postdoctoral fellows, 130 laboratory technicians and administrative staffs, and 200 graduate students.

Firmly believing in the need for the creation of scientific knowledge, PBC pursues fundamental scientific advances through interdisciplinary programs and industry collaborations. The major programs of PBC are biomolecular diversity, vaccine development, specialty rice, and biochip research programs. Not only the Center emphasizes research that will have high impacts on the scientific community, but also focuses on those that can yield high returns on the investment made by business partners including POSCO. Platform technologies and core facilities are being provided to the members in order to promote potential application of the technologies developed on campus. Also, its educational and training programs are designed to prepare the participants well for the scientific challenges of the post-genome era.

The ultimate success of the Center largely depends upon the quality of scientific knowledge and its commercial applications it has, and the people who work for that. The Center will sustain its excellent manpower by well maintaining its present scientists and recruiting more in the future depending on the needs, and we are strongly determined to grow into a world-class research institute that ultimately contributes to the betterment of human welfare. For success, the Center will develop its growth strategy based on increasing pool of skilled scientists in the future to become a world class institute dedicated to improving human society as well as being engine of growth for Korean biotechnology

 
 
Introducing POSTECH...
 

The Pohang University of Science and Technology, called POSTECH in short, was founded in 1986 as a research-oriented university with the support from the POSCO, Co., Ltd., a world-class steel producer, under the mission to educate young future leaders who can contribute to the national prosperity through advancement in science and technology.

POSTECH from the very beginning had positioned itself as a first class university in the nation by recruiting outstanding faculty from both at home and abroad, attracting top-notch students, and providing them with optimal environments for research and education. Despite its short history, POSTECH has ranked the top in national assessments and was rated as the best science and technology university in South East Asia by Asiaweek magazine in 1998. And in the annual evaluation of universities in Korea by Joongang Daily News, a leading national newspaper, has rated POSTECH the top three times over the last decade.

The total of 210 faculty members are engaged in active research and education in four basic science departments (Mathematics, Physics, Chemistry, Life Science) and six engineering departments (Mechanical, Electrical, Computer, New Materials, Industrial, Chemical). There are about 2,800 students with high academic standards ? 1,200 in undergraduate and 1,600 in graduate programs. The flexibility enjoyed being a small-size university allows close interactions between faculty and students. Furthermore, since s tudents as well as professors live on or near campus, a unique, a close-knit community of professionals is formed, which ensures high efficiency in academic and research activities.

As the first research-oriented university in the nation, POSTECH houses many of the state-of-the-art research facilities and equipments, including a third generation 2.5GeV synchrotron radiation source. Empowered with outstanding research manpower and facilities, the University headquarters many research labs and centers on a national level. Thanks to the dedicated work of research professionals and students, POSTECH professors enjoy the highest number of SCI publications per professor in the nation, comparable with that of other prestigious universities abroad.

All students are provided with on-campus accommodations at a nominal cost, while married graduate students are assigned to one-bedroom flats. Most undergraduate students enjoy scholarships of various kinds, recovering 55% of their tuition. All graduate students are fully supported by either teaching or research assistantship

< Pohang Accelerator Laboratory (PAL)>
One of the major on-campus research facilities that plays a critical role in structural analysis among others is the Pohang Accelerator Laboratory (PAL), which is located within walking distance from the Center buildings. PAL, a third generation of 2.5 GeV synchrotron radiation source, completed a beamline for protein crystallography in fall 2001 providing extremely bright X-ray and vacuum ultraviolet (VUV) light. This puts professors of life sciences, particularly those who are in structural biology and molecular medicine, in a leading position in these fields. To name a few, Professors Changill Ban, Yunje Cho and Byung Ha Oh are engaged in conducting intensive research using PAL facility.

 
 
Main Research Activities
 
Strategic Research Projects

Nanoscale controlled surface for genomics and proteomics (Dr. Joon Won Park)

Efficacy test of sGX-109 in macaque AIDS model (Dr. Young Chul Sung)

Finctional genomics by T-DNA insertional mutagenesis and improvement of rice grain

  quality through metabolic analysis (DR. Gynheung An)
 
Frontier Research Projects

Molecular medicine: 6 projects

Plant biotechnology: 4 projects

Nanobiotechnology: 6 projects

 
Platform Research Support Programs

Platform technology for the screening and analysis of biomolecular diversity

Platform technology for development of vaccines

Basic service program for functional genomics of rice

Nanobio platform technology

Utilization of centralized equipment of PBC

 
 
Core Tech Facilities
 
 
 
 
 
 
Bio-Molecular Diversity

Equipments
Automatic multi-peptide synthesizer
(Advanced Chem Tech)
Manual peptide synthesizer (DuPont)
Mass spectrometers

   
Histology

Tissue Embedding System
Confocal laser scanning microscope

   
BioAFM Multiprobe S, VT AFM & STM 25 DRH
   
Biochip Facility

HS4800 Hybridization Station
Array WoRx Biochip Reader (AWE)

   
NMR 300MHz FT-NMR Spectrometer
   
Laser Micro Machining/ Mask Aligner
   
Biomedical Lab-on-a-chip

Laser micro machining ( MBD VUV 193nm microtech camera beam delivery assembly to IX-100weldment frame and granite, Lamda physic LPX refurbished laser with nova tube)
Wafer bonder (TPS-100M-ALI)

   
Germ-free Animal Facility Microinjection equipment ( Transferman NK2. Injectman NI2. Microscope-Axiovert200
   
FACS

FACS (FACSVantage SE)
FACS (FACSCalibur)

   
DNA Sequencing Facility DNA Sequencer (AB3730 DNA Analyzer)
   
High Through Put Screening Facility

Automated Liquid Handling System
Cell based screening system (InCell)

   
Advanced Microscopy Imaging Facility

Confocal laser scanning microscopy
(LSM 510 META )
Transmission electron microscopy
(JEM-1011)

   
Protein Analysis Facility

FT-IR spectrometer (Equinox 55)
Differential Scanning Calorimeter (VP-DSC)
Spectropolarimeter (JASCO J-810)

 
 
Technology Transfer
 

PBC's Technology Transfer Team aims to effectively transfer PBC technologies to the market so as to generate benefits for PBC and POSCO. For this goal, the team is involved in providing a full set of services to ensure effective technology transfer and business development.

What does the Technology Transfer Team do?
- Facilitate invention disclosure and patenting
- Proactively seek licensees and negotiate
- Analyze potential opportunities to form a start-up and provide hands-on business assistance

Who are doing the job?
Dongil Han, Ph.D. ? Molecular Medicine

Dr. Han has over fifteen years of experience in the pharmaceutical industry sector (R&D experience at SK Corp. in Korea and business development VP at SK Biopharm in NJ) holds a PhD in Organic Chemistry from KAIST.
Sangjae Lee ? Plant Bio and Nano Bio
Mr. Lee has ten years of experience in the biotech industry sector (Corporate planning experience in Korea and business development at Protein Pharma. in MA) and holds a MS in Neuroscience from Syracuse University .

Available Technologies

Biotherapeutics
Licensing Manager: Dongil Han, Ph.D. / 82-54-279-8353 /
dongilhan@postech.ac.kr
Cancer
Transcriptional coactivator ASC-2 protein as an anti-arteriosclerotic target
CNS
Novel peptides for inhibiting the binding of VEGF to ет-amyloid
Novel peptides for inhibiting the formation of ет-amyloid
Immune/Inflammagory
Therapeutic peptides enhancing an immune response
Peptides modulating an immune response in human
Peptides modulating an immune response in human
rIL-12 encapsulated with biodegradable microspheres as a vaccine adjuvant
Vaccine adjuvant with excellent immunity for treatment of viral infection
Leukocyte-activating peptides
IL-12p40 subunit mutant genes for DNA vaccine adjuvant
Drug Delivery
Enhanced targeting of drug delivery with nucleoside based phospholipids
2'-deoxyuridine derivatives useful for drug delivery system
Biotech Tools

Licensing Manger: Sangjae Lee / 82-54-279-8648 / sjleebio@postech.ac.kr
Bioengineering
Large scale production of mussel adhesive protein
Biosynthesis
Synthetic method for optically active alcohol
Phosphoramidites for synthesis of oligodeoxynucleotide
Synthetic methods for chiral hydroxyester compounds
Synthetic method for chiral amines

Nanobiotechnology

Licensing Manger: Sangjae Lee / 82-54-279-8648 / sjleebio@postech.ac.kr
Biochip
Gold standard substrate for biochip applications
Chip for diagnosing pathogenic microorganism
BioMEMS
High-throughput continuous multiplex PCR device
Electrochemical DNA hybridization detection technology

Plant Biotechnology

Licensing Manger: Sangjae Lee / 82-54-279-8648 / sjleebio@postech.ac.kr
Gene/Transgenics
High quality rice development by using an organ specific gene
Development of monocotyledonous mutant by using T-DNA tagging vector
T-DNA insertional mutant pool of Japonica rice
Plant aging control by using leaf life span regulating genes
Flowering time control by using COG gene
Phytoremediation
Transgenic plants with improved cadmium resistance and extraction for phytoremediation
Transgenic plants with improved resistance and extraction capacity of heavy metals/pesticides
Transgenic plants with enhanced resistance and decreased uptake of heavy metals

 
 
Start-up Companies
 

SIGMOL http://www.sigmol.com
SIGMOL, Inc. aims to grow into a leading biotechnology company by providing a solution for molecular medicine.  SIGMOL was established in June, 2000, to capitalize on the knowledge and experiences which have been accumulated over the last decade in the Signal Transduction laboratory, POSTECH.  The company name, SIGMOL, is abbreviated from SIGnaling MOLecules, which is the basic language to understand a variety of physiological phenomena.
GENEXIN http://www.genexin.com
PANBIONET
http://www.panbionet.com
GENOMINE
http://www.genomine.com
NEUROMEX
http://www.neuromex.co.kr
ENVISIGN
http://www.envisign.com

 
 
Administration
 

The Administrative Service Team aims to provide administrative supports for efficient implementation of core researches and commercialization programs of the Center so that the research output can be maximized. Major services of the Administrative Service Team provided for the faculty and research staff who are conducting the Center programs and projects include:
•  Budget planning
•  Patent administration
•  Events planning & Community Service
•  Administration of government, industry, and POSCO projects
•  Purchase, asset management
•  Center PR and homepage maintenance, IP control
•  Waste disposal, hygiene, fire control, security