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About
the POSTECH Biotech Center |
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| The Postech Biotech Center (PBC) was established in November 2000
in collaboration with POSCO, a world leader in steel industry and
the founder of POSTECH, with the mission to grow into a world class
biotech center that carries out cutting edge research and trains
future leaders in biotechnology. The rationales behind this grandeur
project of the nation ' s finest life-science research complex between
academia and industry are to leverage the academic excellence achieved
by POSTECH over the last decade, and to diversify the business portfolio
of POSCO in an increasingly stagnant environment into the promising
business of biotechnology.
The Center ' s four-story building (14,000 m 2 ), whose construction
work started from December 2002 and was completed in July 2003, is
characterized of the concept of Open Laboratories (no walls in between
laboratories) to facilitate easy communication and exchange of ideas
for collaborations beyond the boundaries of research. It also provides
a wide range of state-of-the-art core technology facilities and a
large number of specialty facilities including clean rooms for nanobiotech,
green house, and germ-free animal rooms.
Following the lead of Professor Chi-Bom Chae, Head of the Division
of Molecular and Life Sciences, the Center is empowered with a total
of 35 professors with outstanding scientific achievements in biology,
physics, chemistry, chemical engineering, and mechanical engineering.
They are supported by a group of 90 postdoctoral fellows, 130 laboratory
technicians and administrative staffs, and 200 graduate students.
Firmly believing in the need for the creation of scientific knowledge,
PBC pursues fundamental scientific advances through interdisciplinary
programs and industry collaborations. The major programs of PBC are
biomolecular diversity, vaccine development, specialty rice, and
biochip research programs. Not only the Center emphasizes research
that will have high impacts on the scientific community, but also
focuses on those that can yield high returns on the investment made
by business partners including POSCO. Platform technologies and core
facilities are being provided to the members in order to promote
potential application of the technologies developed on campus. Also,
its educational and training programs are designed to prepare the
participants well for the scientific challenges of the post-genome
era.
The ultimate success of the Center largely depends upon the quality
of scientific knowledge and its commercial applications it has, and
the people who work for that. The Center will sustain its excellent
manpower by well maintaining its present scientists and recruiting
more in the future depending on the needs, and we are strongly determined
to grow into a world-class research institute that ultimately contributes
to the betterment of human welfare. For success, the Center will
develop its growth strategy based on increasing pool of skilled scientists
in the future to become a world class institute dedicated to improving
human society as well as being engine of growth for Korean biotechnology |
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Introducing
POSTECH... |
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The Pohang University of Science and Technology, called POSTECH
in short, was founded in 1986 as a research-oriented university
with the support from the POSCO, Co., Ltd., a world-class steel
producer, under the mission to educate young future leaders who
can contribute to the national prosperity through advancement in
science and technology.
POSTECH from the very beginning had positioned itself as a first
class university in the nation by recruiting outstanding faculty
from both at home and abroad, attracting top-notch students, and
providing them with optimal environments for research and education.
Despite its short history, POSTECH has ranked the top in national
assessments and was rated as the best science and technology university
in South East Asia by Asiaweek magazine in 1998. And in the annual
evaluation of universities in Korea by Joongang Daily News, a leading
national newspaper, has rated POSTECH the top three times over
the last decade.
The total of 210 faculty members are engaged in active research
and education in four basic science departments (Mathematics, Physics,
Chemistry, Life Science) and six engineering departments (Mechanical,
Electrical, Computer, New Materials, Industrial, Chemical). There
are about 2,800 students with high academic standards ? 1,200 in
undergraduate and 1,600 in graduate programs. The flexibility enjoyed
being a small-size university allows close interactions between
faculty and students. Furthermore, since s tudents as well as professors
live on or near campus, a unique, a close-knit community of professionals
is formed, which ensures high efficiency in academic and research
activities.
As the first research-oriented university in the nation, POSTECH
houses many of the state-of-the-art research facilities and equipments,
including a third generation 2.5GeV synchrotron radiation source.
Empowered with outstanding research manpower and facilities, the
University headquarters many research labs and centers on a national
level. Thanks to the dedicated work of research professionals and
students, POSTECH professors enjoy the highest number of SCI publications
per professor in the nation, comparable with that of other prestigious
universities abroad.
All students are provided with on-campus accommodations at a nominal
cost, while married graduate students are assigned to one-bedroom
flats. Most undergraduate students enjoy scholarships of various
kinds, recovering 55% of their tuition. All graduate students are
fully supported by either teaching or research assistantship
< Pohang Accelerator Laboratory (PAL)>
One of the major on-campus research facilities that plays a critical
role in structural analysis among others is the Pohang Accelerator
Laboratory (PAL), which is located within walking distance from the
Center buildings. PAL, a third generation of 2.5 GeV synchrotron
radiation source, completed a beamline for protein crystallography
in fall 2001 providing extremely bright X-ray and vacuum ultraviolet
(VUV) light. This puts professors of life sciences, particularly
those who are in structural biology and molecular medicine, in a
leading position in these fields. To name a few, Professors Changill
Ban, Yunje Cho and Byung Ha Oh are engaged in conducting intensive
research using PAL facility. |
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Main
Research Activities |
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| Strategic
Research Projects |
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Nanoscale controlled surface for genomics
and proteomics (Dr. Joon Won Park) |
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Efficacy test of sGX-109 in macaque AIDS model (Dr.
Young Chul Sung) |
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Finctional genomics by T-DNA insertional mutagenesis
and improvement of rice grain |
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quality through metabolic analysis (DR. Gynheung An) |
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| Frontier
Research Projects |
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Molecular medicine: 6 projects |
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Plant biotechnology: 4 projects |
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Nanobiotechnology: 6 projects |
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| Platform
Research Support Programs |
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Platform technology for the
screening and analysis of biomolecular diversity |
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Platform technology for development of
vaccines |
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Basic service program for functional
genomics of rice |
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Nanobio platform technology |
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Utilization of centralized equipment
of PBC |
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Core
Tech Facilities |
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| Bio-Molecular Diversity |
Equipments
Automatic multi-peptide synthesizer
(Advanced Chem Tech)
Manual peptide synthesizer (DuPont)
Mass spectrometers |
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| Histology |
Tissue Embedding System
Confocal laser scanning microscope |
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| BioAFM |
Multiprobe S, VT AFM & STM 25 DRH |
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| Biochip Facility |
HS4800 Hybridization Station
Array WoRx Biochip Reader (AWE) |
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| NMR |
300MHz FT-NMR Spectrometer |
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| Laser Micro Machining/ |
Mask Aligner |
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| Biomedical Lab-on-a-chip |
Laser micro machining ( MBD VUV 193nm microtech camera
beam delivery assembly to IX-100weldment frame and granite,
Lamda physic LPX refurbished laser with nova tube)
Wafer bonder (TPS-100M-ALI) |
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| Germ-free Animal Facility |
Microinjection equipment ( Transferman NK2. Injectman
NI2. Microscope-Axiovert200 |
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| FACS |
FACS (FACSVantage SE)
FACS (FACSCalibur) |
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| DNA Sequencing Facility |
DNA Sequencer (AB3730 DNA Analyzer) |
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| High Through Put Screening Facility |
Automated Liquid Handling System
Cell based screening system (InCell) |
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| Advanced Microscopy Imaging Facility |
Confocal laser scanning microscopy
(LSM 510 META )
Transmission electron microscopy
(JEM-1011) |
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| Protein Analysis Facility |
FT-IR spectrometer (Equinox 55)
Differential Scanning Calorimeter (VP-DSC)
Spectropolarimeter (JASCO J-810) |
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Technology
Transfer |
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PBC's Technology Transfer Team aims to effectively transfer
PBC technologies to the market so as to generate benefits for PBC
and POSCO. For this goal, the team is involved in providing a full
set of services to ensure effective technology transfer and business
development.
What does the Technology Transfer Team do?
- Facilitate invention disclosure and patenting
- Proactively seek licensees and negotiate
- Analyze potential opportunities to form a start-up and provide hands-on business
assistance
Who are doing the job?
Dongil Han, Ph.D. ? Molecular Medicine
Dr. Han has over fifteen
years of experience in the pharmaceutical industry sector (R&D
experience at SK Corp. in Korea and business development VP at SK
Biopharm in NJ) holds a PhD in Organic Chemistry from KAIST.
Sangjae
Lee ? Plant Bio and Nano Bio
Mr. Lee has ten years of experience in
the biotech industry sector (Corporate planning experience in Korea
and business development at Protein Pharma. in MA) and holds a MS
in Neuroscience from Syracuse University .
Available Technologies
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| Biotherapeutics |
Licensing Manager: Dongil Han, Ph.D. /
82-54-279-8353 /
dongilhan@postech.ac.kr
Cancer
Transcriptional coactivator ASC-2 protein as an anti-arteriosclerotic target
CNS
Novel peptides for inhibiting the binding of VEGF to ет-amyloid
Novel peptides
for inhibiting the formation of ет-amyloid
Immune/Inflammagory
Therapeutic peptides enhancing an immune response
Peptides modulating an immune
response in human
Peptides modulating an immune response in human
rIL-12 encapsulated with biodegradable
microspheres as a vaccine adjuvant
Vaccine adjuvant with excellent immunity for
treatment of viral infection
Leukocyte-activating peptides
IL-12p40 subunit mutant genes for DNA vaccine adjuvant
Drug Delivery
Enhanced targeting of drug delivery with nucleoside based phospholipids
2'-deoxyuridine
derivatives useful for drug delivery system |
| Biotech Tools |
Licensing Manger: Sangjae Lee / 82-54-279-8648 / sjleebio@postech.ac.kr
Bioengineering
Large scale production of mussel adhesive
protein
Biosynthesis
Synthetic method for optically active alcohol
Phosphoramidites
for synthesis of oligodeoxynucleotide
Synthetic methods for chiral
hydroxyester compounds
Synthetic method for chiral amines |
| Nanobiotechnology |
Licensing Manger: Sangjae Lee / 82-54-279-8648 / sjleebio@postech.ac.kr
Biochip
Gold standard substrate for biochip applications
Chip for
diagnosing pathogenic microorganism
BioMEMS
High-throughput continuous multiplex PCR device
Electrochemical
DNA hybridization detection technology |
| Plant Biotechnology |
Licensing Manger: Sangjae Lee / 82-54-279-8648 / sjleebio@postech.ac.kr
Gene/Transgenics
High quality rice development by
using an organ specific gene
Development of monocotyledonous mutant
by using T-DNA tagging vector
T-DNA insertional mutant pool of
Japonica rice
Plant aging control by using leaf life span regulating
genes
Flowering time control by using COG gene
Phytoremediation
Transgenic plants with improved cadmium resistance and extraction
for phytoremediation
Transgenic plants with improved resistance
and extraction capacity of heavy metals/pesticides
Transgenic
plants with enhanced resistance and decreased uptake of heavy
metals |
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Start-up
Companies |
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SIGMOL http://www.sigmol.com
SIGMOL, Inc. aims to grow
into a leading biotechnology company by providing a solution for
molecular medicine. SIGMOL was
established in June, 2000, to capitalize on the knowledge and experiences
which have been accumulated over the last decade in the Signal
Transduction laboratory, POSTECH. The company name, SIGMOL,
is abbreviated from SIGnaling MOLecules, which is the basic language
to understand a variety of physiological phenomena.
GENEXIN http://www.genexin.com
PANBIONET http://www.panbionet.com
GENOMINE http://www.genomine.com
NEUROMEX http://www.neuromex.co.kr
ENVISIGN http://www.envisign.com |
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Administration |
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The Administrative Service Team aims to provide administrative
supports for efficient implementation of core researches and commercialization
programs of the Center so that the research output can be maximized.
Major services of the Administrative Service Team provided for
the faculty and research staff who are conducting the Center programs
and projects include:
Budget planning
Patent administration
Events planning & Community
Service
Administration of government, industry, and POSCO
projects
Purchase, asset management
Center PR and homepage
maintenance, IP control
Waste disposal, hygiene, fire control,
security |
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